The European Commission published a rescript related to the Biotechnology and Biomanufacturing start-up, which offers opportunities for the EU to lead in scaling innovative new industries. This rescript summarizes the current challenges and obstacles in biotechnology and biomanufacturing and also proposes actions, such as international dialogue and cooperation, to handle these challenges in a timely manner, in accordance with the rescript on the Long-Term Competitiveness of the EU.