The rapid development of 3D printing technology is providing innovative solutions, particularly in the food industry, addressing various nutritional needs and sustainability concerns. This review, published in the Comprehensive Review journal, explores critical considerations in large-scale 3D food printing, emphasizing food safety and focusing on topics such as pathogen control, machine hygiene, and the impact on macronutrients. Additionally, it addresses post-processing factors and outlines the limitations and opportunities in the implementation of 3D food printing.